ppat.1012079.s002.tif (1.4 MB)
Metabolic parameters of OCR and ECAR shown in Fig 2 and dose-dependent effect of HBeAg on the OCR of THP-1 macrophages.
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posted on 2024-03-11, 17:41 authored by Yumei Li, Christine Wu, Jiyoung Lee, Qiqi Ning, Juhyeon Lim, Hyungjin Eoh, Sean Wang, Benjamin P. Hurrell, Omid Akbari, Jing-hsiung James Ou(A-B), (D-E) and (F-G) are the quantitative analyses of the metabolic parameters of OCRs and ECARs of Fig 2A–2C, respectively. (C) Analysis of the OCR of THP-1 macrophages that were treated with 0.25, 0.5 or 1 μg/mL of HBeAg for 48 hours. THP-1 macrophages not treated (Mock) was used as the control. N.S., not significant; *, p<0.05; **, p<0.01; ***, p<0.001.
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tricarboxylic acid cycleopposite metabolic activitieslow oxidative phosphorylationlow glycolytic activitiesimportant metabolic intermediatehigh glycolytic activitieshepatitis b virusatypical metabolism inducedassociated protein 3xlink "> macrophagesreprogram mitochondrial metabolismlike receptor 4hbv e antigenhbeag also enhancesdisplay high oxphoslike macrophages inducedlike proinflammatory polarizationmacrophages like macrophagesmacrophages dependingmitochondrial genesinflammatory polarizationlike antivia tollpromote oxphosinduce deathhbv attenuateshbeag leadshbeag ),antiviral response
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