Memory CD4⁺ T cells repopulated faster than naïve CD4⁺ T cells in blood following termination of antibody treatment.

The frequency of naïve (A, CD27⁺CD45RA⁺), central memory (B, CD27⁺CD45RA^-), and effector memory (C, CD27^-CD45RA^-) CD4⁺ T cells in the peripheral blood was longitudinally determined by flow cytometry. Blue arrows in A show the timing of 4 anti-CD4 antibody administrations to the anti-CD4 antibody treatment group. Anti-CD4 antibody treated animals (n = 6) are shown in red; control animals (n = 4) are shown in black. Data are expressed as mean ± SEM. Statistical analyses were performed using unpaired two-sided Mann–Whitney U-tests. Statistical significance was considered when P < 0.05.

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