pgen.1009992.s004.jpg (35.06 kB)
Members of the Toll signalling pathway are involved in maintaining the intestinal bacteriome.
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posted on 2022-01-10, 18:27 authored by Shivohum Bahuguna, Magda Atilano, Marcus Glittenberg, Dohun Lee, Srishti Arora, Lihui Wang, Jun Zhou, Siamak Redhai, Michael Boutros, Petros Ligoxygakis(A)PGRP-SAseml flies showed a significant reduction in lifespan. Sex-specific pairwise statistical comparisons were conducted using the log-rank test (***p<0.001). (B) spzrm7 flies showed significantly reduced intestinal CFUs. Statistical comparisons were conducted using student’s t-test (ns = not significant, ***p<0.001).
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results give insightsenabled fat catabolismdiv >< prestored bacterial densityintestinal bacterial densitymaintain indigenous bacteriabacterial recognition upstreamtoll activated 4eκb signalling resultedbacterial recognitionreduced densitydownstream signallinggut bacteriacommensal bacteriatranscriptional targettoll activitypharmacological inhibitionmetabolic parametershealthy fliesgut setsfeedback loopdrosophila >, deficiency
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