pone.0254305.g003.tif (427.04 kB)
Mass spectrometry analysis.
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posted on 2021-09-30, 17:30 authored by Nikita Lomis, Susan Westfall, Dominique Shum-Tim, Satya PrakashHSA (lower) and AT1-HSA (upper) was analyzed by Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry. The m/z ratio of the AT1-HSA peak was at least 7000 higher than that of the HSA peak, which demonstrated that AT1 was successfully conjugated to the surface of HSA.
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lacking target specificityexhibits low bioavailabilityexhibit superior targetingcovalent conjugation reaction9 ± 18 ± 2improves myocardial contractility4 ± 14 %, respectively2 ± 4overexpressing at1 receptorsh9c2 cells treateddrug delivery characteristicsdiv >< pcongestive heart failuretargeted cardiac uptakeheart failureh9c2 cellstargeted drugtargeted deliverymyocardial infarctioncardiac functionzeta potentialvs 44vivo vasodilatory effectssurface functionalizedsignificantly highernanoparticle sizeintracellular uptakehypertrophic conditionscumulative releaseangiotensin ii7 nm7 mv24 hrs
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