pgen.1010777.s002.tif (12.02 MB)
Mapping back of perfect markers to CS19 human valve sections.
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posted on 2023-11-27, 19:20 authored by Rachel Queen, Moira Crosier, Lorraine Eley, Janet Kerwin, Jasmin E. Turner, Jianshi Yu, Ahlam Alqahtani, Tamilvendhan Dhanaseelan, Lynne Overman, Hannah Soetjoadi, Richard Baldock, Jonathan Coxhead, Veronika Boczonadi, Alex Laude, Simon J. Cockell, Maureen A. Kane, Steven Lisgo, Deborah J. HendersonPerfect marker genes (see Fig 2) for a range of cardiac progenitor cell types (neural crest cells), differentiated cardiac cell types (cardiomyocytes, cushion tissue, fibrous tissue, endocardium, smooth muscle cells), haematopoietic cell types that are known to be found in the heart (red blood cells, lymphocytes, macrophages) and those that are known to be similar to cushion tissue (bone, cartilage), were mapped back to the CS19 human valve sections used for the ST analysis.
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xlink "> abnormalitiesusing spatial transcriptomicsseveral days apartnovel &# 8221highlight &# 8220common congenital defectsgenomic data analysesexpression data confirmarterial valves formdeveloping heart valvesdeveloping arterial valvesrelated genes maydifferentially expressed genesmouse atrioventricular valvesarterial valve defectssignalling pathways importantarterial valve developmentarterial valvesgenes importantdeveloping embryodata suggestsvalve developmentmouse knockoutsmouse genomecardiac developmentvalve transcriptomestiny structuresstill muchsmall sizesignificant causerelative inaccessibilitylater lifeincluding fourhuman gestationhuman embryosgreat majoritygenetic levelcausative variantsaccurately dissecting
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