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MIC distribution and polymyxin B resistance in carbapenem-resistant Klebsiella pneumoniae, January 2010—December 2019.

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posted on 2024-01-26, 18:31 authored by Ingvar Ludwig Augusto de Souza, Paola Cappellano, Diogo Boldim Ferreira, Maria Daniela Bergamasco, Thomas Cardoso das Chagas Neto, Fabio Rodrigues Kerbauy, Otavio Carvalho Guimarães Baiocchi, Antonio Carlos Campos Pignatari

Minimum inhibitory concentrations distribution and proportion of polymyxin B resistance among carbapenem-resistant Klebsiella pneumoniae isolates from January 2010 to December 2019. (A) Absolute number of samples distributed according to the minimum inhibitory concentrations obtained by broth microdilution of 45 carbapenem-resistant Klebsiella pneumoniae isolates. Susceptibility (light grey), resistance (dark grey). (B) Percentages of susceptible (light grey) and resistant (dark grey) polymyxin B isolates amidst 65 episodes of carbapenem-resistant Klebsiella pneumoniae bloodstream infections, yearly stratified. Notes: CRKp—carbapenem-resistant Klebsiella pneumonia; MIC–Minimum inhibitory concentration.

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    polymyxin b comucosal barrier injuryklebsiella pneumoniae invasive fungal diseaseadjusted hazard ratio9 %, respectively06 – 0microbiological data revealed20 – 7year brazilian cohortpolymyxin b resistantdiv >< pbsi episodes occurringbacterial bloodstream infections40 – 10ci ]: 0ahr ]: 014 – 0day mortality crkpyear cohortbloodstream infectionsday mortalitymicrobiological aspectsmortality rates7 %).7 %)retrospectively studiedresistance phenotyperegarding treatmentprimary causeoverall survivalless commonjanuary 2010hsct recipientshsct ).haematological patientshaematological malignancieshaematological malignancesgastrointestinal tractfavorable correlationdescribe clinicaldeemed appropriatedecember 2019confidence intervalcombination therapyclinical impactbsi causedbetter outcomeamikacin resistanceacute leukemias65 crkp6 %)31 patients16 samples14 individuals002 ).

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