pone.0256907.g002.tif (3.53 MB)
Lymphocyte segmentation.
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posted on 2021-09-23, 17:31 authored by Panagiotis Barmpoutis, Matthew Di Capite, Hamzeh Kayhanian, William Waddingham, Daniel C. Alexander, Marnix Jansen, Francois Ng Kee Kwong(a) input 10x H&E-stained image, (b) lymphocytes identification -red dots, (c) separation of merged or overlapped cells through the proposed ellipsoidal modelling, (d) detailed image of single-cell segmentation.
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standardised method availablemathematical criteria definingimproved cancer prognosistertiary lymphoid structureshistopathologists ’ assessmente histology slidestained digital slidese slides implyingdiv >< p2 minimum tls areasensitivity level basedlymphocytes within tls>< supe slidestls areaminimum numberlymphoid cellslymphocytes withindensity assessmenttls regionsused immunohistochemistrytumoral tissuestrue numbersubsequently determinedstandard deviationspecific cellsrespectively comparedprevious studiesgreat accuracyellipsoidal modelectopic aggregateseasily recognizeddiscrete entitiesdigital hautomated approach>&# 9563 times0128 /<004 /<0026 /<001 /<
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