pone.0294603.g003.tif (2.12 MB)

Longitudinal characterization of serum proteome signature.

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posted on 2024-02-29, 18:23 authored by Samantha M. Powell, Leah G. Jarsberg, Erin L. M. Zionce, Lindsey N. Anderson, Marina A. Gritsenko, Payam Nahid, Jon M. Jacobs

(A) Changes across time of the 676 significant proteins, (B) the distribution of the significant proteins by time point, and (C) the fold changes of the 124 unique proteins at 52 weeks (See S6 Table in S1 File for more detail).

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provided indicative markers proteins uniquely significant like growth factor immune modulated responses identify surrogate markers culture conversion status almost exclusively downregulated proteome signatures collapsed differential proteome signatures week results showed later time periods discrete expression profiles global proteome signature ms proteomic platform integrin signaling maintained treatment progression within statistical differences across 26 weeks respectively xlink "> serum xlink ">serum proteome proteome changes treatment progression time course severity signature expression dynamics compared across 52 weeks 26 weeks week timepoint treatment endpoints treatment 52 though interestingly sensitive lc pulmonary tuberculosis primarily focused metabolism annotations longitudinal analysis largest number initial effects infectious disease disease severity comprehensive assessment compared using better understanding also highlights

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