ppat.1010064.g004.tif (2.84 MB)
List of immunomodulatory schistosome proteins and their major effects.
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posted on 2021-12-30, 18:22 authored by Sreemoyee Acharya, Akram A. Da’dara, Patrick J. SkellyADP, adenosine diphosphate; AMP, adenosine monophosphate; ATP, adenosine triphosphate; Breg, regulatory B cell; DC, dendritic cell; HDM, helminth defense molecule; IL-1ra, IL-1 receptor antagonist a; LPS, lipopolysaccharide; NAD, nicotinamide adenine dinucleotide; polyP, polyphosphate; SmAF, S. mansoni apoptosis factor; SmTCTP, S. mansoni translationally controlled tumor protein; Treg, regulatory T cell.
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proinflammatory anionic polymerplatelet activator adpmolecular mechanisms usedintravascular parasitic platyhelminthsinteractive tegumental ectoenzymesimmune cell functiong ., smcb1g ., sm16g ., pge2g ., lysog ., lnfpiiipgd2 &# 8212biomolecules &# 8212alarmin &# 8221xlink "> schistosomesadult worms expresslpc ), producedbend host biochemistryseveral life stageslipid immunomodulator sphingosineinflammatory mediator adenosineindividually shown capableschistosome immunomodulators describedhost cells integrate&# 8220schistosomes employschistosome glycanssmnpp5 ),worms releasesj16 ).produce eicosanoidsnucleic acidnovel therapeuticsmacrophages ).long livedlisted moleculesinvasive cercariaeinducing aspectsconvert ampcontaining micrornasblood flukesalternatively activatedadditionally cleave
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