pone.0296894.s005.tif (1.4 MB)
Leave-one-out results demonstrated no individual SNPs that could significantly affect the causal effects of AST on DR.
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posted on 2024-01-17, 18:31 authored by Yang Li, Qiu Zhang(A) is for AST on DR overall. (B) is for AST on T2DM with DR.
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wide association studysup >&# 8722single nucleotide polymorphismspotential biological mechanismspleiotropy residual summultivariable mendelian randomization5 × 10serum aspartate aminotransferaseserum alanine aminotransferasewide significance (<independent causal effectdiabetic microvascular complicationsalp ), gamma206 – 1115 – 1univariable mendelian randomizationthree mvmr approachesprevious observational investigationsfive uvmr approachesdiabetes risk factorsindependent causal effectsggt ),diabetic retinopathyclinical significancecausal effectscausal associationsserum altuvmr revealeduk biobanksignificant associationssensitivity analysesminimization methodsliver enzymeslevel statisticslevel increasedglutamyl transferasegenetic instrumentsfinngen consortiumextended versionsearly preventionalkaline phosphatase017 ).006 ).
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