pone.0297861.s001.tif (811.58 kB)
Leave-one-out of SNPs associated with malignant tumor of kidney and their risk of different types of systemic autoimmune diseases after outliers removal with MR-PRESSO and tightening instrument P value threshold.
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posted on 2024-02-29, 18:46 authored by Puyu Liu, Jihang Luo, Lanlan Zhao, Qingqing Fu, Yao Chen, Chengfang Li, Jieyu Xu, Xiaorong YangLeave-one-out of SNPs associated with malignant tumor of kidney and their risk of different types of systemic autoimmune diseases after outliers removal with MR-PRESSO and tightening instrument P value threshold.
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systemic autoimmune diseaseseveral autoimmune diseasesquality control stepsprovide new insightssubacute iridocylitis (<single snp analysisconsistent without heterogeneity>), juvenile rheumatismanalyze genetic causalityinverse variance weightingwide association studyivw ), mrgenetic causalitywide genomevariance weightedcoxarthrosis (<study suggestsstudy exploresgwas ),evaluate causality897 ),xlink ">weighted modelweighted mediantemporal naturetake seriouslysimple modelsensitivity analysisscale genomerenal malignancyrenal malignanciespotential riskpotential impactpooled datapleiotropic testingodds ratiomultiple malignanciesinstrumental variablesincreased riskevaluate pleiotropydifficulty indeterminingconfidence intervalcausal relationship869 483 1 077 073 051 014 009 008 006 002
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