pone.0254125.g004.tif (456.67 kB)
LL/2-tdTomato/Luc tumor growth is inhibited by CD4+ T cells, CD8+ T cells and NK cells in vivo.
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posted on 2021-08-19, 17:27 authored by Lei Huang, Ramireddy Bommireddy, Luis E. Munoz, Rohini N. Guin, Changyong Wei, Amanda Ruggieri, Ashwathi P. Menon, Xiaoxian Li, Mala Shanmugam, Taofeek K. Owonikoko, Suresh S. Ramalingam, Periasamy Selvaraj(A) Experimental design of in vivo cell depletion study (n = 5). (B) Tumor growth and (C) tumor-free survival. Data were analyzed by unpaired student t-tests on day 30. Mean ± SEM is plotted. Values of p<0.05 were considered significant. *p < 0.05 LL/2-tdTomato/Luc vs. all the other groups. Tumor-free survival was analyzed using Kaplan-Meier analysis. Values of p<0.05 were considered significant. *p < 0.05 LL/2-tdTomato/Luc vs. all the other groups.
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conduct studiestdTomatotumor-infiltrating lymphocytescell lineLewis lung carcinomaTILtumor microenvironmentmurine lung cancerLLtumor Imaging techniquesanti-CTLA -4 antibodiesgrowth rateimmunocompetent syngeneic tumor tra...visualizing tumor progressionanimal modelstumor-induced myeloid-derived suppr...immunocompetent animal modelstumor growthMDSC
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