Kaplan-Meier survival analyses in patients harboring significant mRNA overexpression and/or amplification of TK genes.

Kaplan-Meier analyses of OS (left panels) and DFS (right panels) in patients harboring significant mRNA overexpression (z-score >2) and/or amplification of (A) group 1 TKs (red) vs. those without alteration (blue; median OS 28.22 vs. 61.40 mos., log-rank p = 0.0308; median DFS 27.99 vs. 82.42 mos., log-rank p = 0.0145); (B) group 2 TKs (red) vs. those without alteration (blue; 46.65 vs. 22.14 mos., log-rank p = 3.197e-4; median DFS 51.41 vs. 19.05 mos., log-rank p = 6.673e-4); (C) group 3 TKs (red) vs. those without alteration (blue; 30.91 vs. 59.26 mos., log-rank p = 0.134; median DFS 27.99 vs. 72.34 mos., log-rank p = 0.0391); (D) 14 ctRTKs (AXL, CSF1R, FLT3, KDR, MET, MERTK, NTRK1/2/3, RET, ROS1, TEK, DDR2 and TYRO3; red) vs. those without alteration (blue; 25.56 vs. 54.86 mos., log-rank p = 0.0289; median DFS 25.23 vs. 55.16 mos., log-rank p = 0.0109).