pone.0254305.g009.tif (148.14 kB)
Intracellular uptake of nanoparticles.
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posted on 2021-09-30, 17:30 authored by Nikita Lomis, Susan Westfall, Dominique Shum-Tim, Satya PrakashIntracellular uptake of MRN-HSA-NPs, AT1-HSA-MRN-NPs and Scr-HSA-MRN-NPs in H9c2 cells (a) Normal cells (non-hypoxic, non-hypertrophic), (b) Hypoxic cells and (c) Hypertrophic cells. The nanoparticle concentration was 0.5 mg/mL. The graph shows a representative result of mean ± SD (n = 3). ****p<0.0001 was considered highly significant and ***p<0.001, **p<0.01 were considered significant based on Tukey’s posthoc analysis.
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lacking target specificityexhibits low bioavailabilityexhibit superior targetingcovalent conjugation reaction9 ± 18 ± 2improves myocardial contractility4 ± 14 %, respectively2 ± 4overexpressing at1 receptorsh9c2 cells treateddrug delivery characteristicsdiv >< pcongestive heart failuretargeted cardiac uptakeheart failureh9c2 cellstargeted drugtargeted deliverymyocardial infarctioncardiac functionzeta potentialvs 44vivo vasodilatory effectssurface functionalizedsignificantly highernanoparticle sizeintracellular uptakehypertrophic conditionscumulative releaseangiotensin ii7 nm7 mv24 hrs
