Induction of autoimmune arthritis in HLA-DR1 mice with WT CII and Cit-CII.

B6.DR1 mice were immunized with native CII or Cit-CII and the incidence (panel A) and severity (panels B, C, and D) of arthritis were monitored. Disease severity was evaluated on the basis of arthritic animals only, and was assessed using a scale of 0 to 4 as described in Materials and Methods. No significant differences were observed in the incidence or severity of disease between the two groups. Data are representative of two independent experiments.