pone.0258426.g003.tif (354.36 kB)
In vitro time kill curves of ceftazidime/avibactam (CEF/AVI), amikacin (AMK), colistin (COL) and tigecycline (TGC) alone and in combinations against KPC-K. pneumoniae (KP48 and KP60 were susceptible to ceftazidime/avibactam, colistin and tigecycline but resistant to amikacin).
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posted on 2021-10-14, 17:42 authored by Fangzhou Wang, Qian Zhou, Xiuwen Yang, Yan Bai, Junchang CuiLine for blank control, △CEF/AVI, ○AMK, ◇COL, □TGC, ●CEF/AVI+AMK, ◆CEF/AVI+COL, ■CEF/AVI+TGC.
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susceptibility testing suggestedminimum inhibitory concentrationhuman health worldwideexhibit better effectagar dilution methodbroth dilution methodtigecycline displayed indifferenceamikacin displayed synergism1 × 10klebsiella pneumoniae synergistic activities testing5 pneumoniae synergistic activitiescheckerboard methodhinton brothvitro k antibacterial activitiessingle drugoptimize multidrugoften inadequatemhb ).major threatline choicekill experimentkill assaysinfection managementdifferent mechanisms2 hospitals14 %).
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