pntd.0009196.g005.tif (204.95 kB)
In vitro profiling of analogues with modifications at the N-alkyl chain.
figure
posted on 2021-02-22, 18:36 authored by Rafael Augusto Alves Ferreira, Celso de Oliveira Rezende Junior, Pablo David Grigol Martinez, Paul John Koovits, Bruna Miranda Soares, Leonardo L. G. Ferreira, Simone Michelan-Duarte, Rafael Consolin Chelucci, Adriano D. Andricopulo, Mariana K. Galuppo, Silvia R. B. Uliana, An Matheeussen, Guy Caljon, Louis Maes, Simon Campbell, Jadel M. Kratz, Charles E. Mowbray, Luiz Carlos DiasND: not determined; SI: selectivity index (CC50 / IC50); a IC50 represented in μM; MLM: mouse liver microsome; b intrinsic clearance represented in μL/min/mg; c calculated logD.
