pone.0256937.s002.tif (1.11 MB)
Impact of RA183 on ES2 cellular bioenergetics.
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posted on 2021-09-10, 17:35 authored by Ravi K. Anchoori, Logan George, Ssu-Hsueh Tseng, Brandon Lam, Srinidhi Polkampally, Anjali D. Amiano, Palmer Foran, Hannah Tsingine, Harideep Samanapally, Fernanda Carrizo Velasquez, Samarjit Das, Deyin Xing, Ahmad Bin Salam, Balasubramanyam Karanam, Chien-Fu Hung, Richard B. S. Roden(A-G) Seahorse assay of ES2 cells upon treatment with 250 nM of RA183 or vehicle (DMSO) for 12 h.
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xlink "> bortezomibproteasome &# 8217monomeric ubiquitin followingcombination approach warrantssynergistic cytotoxic responseirpn13s may compromiseubiquitin receptor rpn13evident upon treatmentcancer cell linesnew candidate irpn13sstress responseovarian cancercell lysatescandidate adrm1ubiquitination playssingle methylshow promiserapid accumulationprototypic inhibitorpotent analogsperinuclear clusteringoxidative stressmitochondrial depolarizationimproved bindingimportant roleearly biomarkercalled ra190asymmetry increasealternative non
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