Immunoreactivity of PrP^Sc in sheep with atypical scrapie.

(A) There is a large amount of PrP^Sc (red color) within the molecular layer of cerebellum in sheep 958 (ARQ/ARQ). (B) PrP^Sc (red color) is confined to the spinal trigeminal tract in the medulla oblongata in sheep 948 (ARQ/ARR). (C) The dorsal motor nucleus of the vagus nerve (circle) is devoid of PrP^Sc in sheep 948. (D) There are multifocal patchy aggregates of PrP^Sc (red color) in the molecular layer of the cerebellum in sheep 943 (VRQ/ARQ). (E) A small amount of PrP^Sc (red color) is present in the retina of sheep 943. (F) In sheep 958 there are large amounts of PrP^Sc (red color) in the plexiform layers of the retina.