pone.0295839.g003.tif (1.86 MB)
Immunohistochemistry (IHC) analysis of BMP8b expression.
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posted on 2023-12-21, 18:53 authored by Nadella Mounika, Angeera Yadav, Parul Kamboj, Sanjay K. Banerjee, Utpal Jyoti Deka, Savneet Kaur, Ramu AdelaIHC analysis was performed in liver tissues of healthy controls and NASH patients. Liver tissues were stained with Hematoxylin and eosin (H&E) staining and then immunostained with BMP8b antibody. A) Control (n = 4), B) F0—No fibrosis (n = 4), C) F2—Moderate fibrosis (n = 4), D) F3—Severe fibrosis (n = 4). The arrows indicate the immune reaction in hepatocytes.
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invasive predictive biomarkersinvasive predictive biomarkerinos -/- fed045 ), aprisignificant positive correlationcirculatory bmp8b levelsbmp8b shows potentialinos -/-) micecdhf ), inosshown high sensitivityincreased bmp8b levelsbmp8b mrna expressionnash ), fibrosiswt mice fednash )study findings confirmedidentify nafld progressionbmp8b expression009 ),significant associationincreased parallelfibrosis scorecdhf dietbmp8b increasesxlink ">wild typesignificantly highersectional studypresent crossnonalcoholic steatohepatitisnafld urgeslarge numberincreasing prevalenceimmunohistochemistry analysishepatocellular carcinomahepatic tissueshepatic tissuehealthy controlsfuture studieselisa kitaspartate aminotransferasealcoholic steatohepatitis91 %)73 %)4 score
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