ppat.1009706.s007.tif (33.57 MB)
Identifying FDA-approved drugs functioning similar to BafA1 and NH4Cl.
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posted on 2021-07-12, 17:46 authored by Chaitra Prabhakara, Rashmi Godbole, Parijat Sil, Sowmya Jahnavi, Shah-e-Jahan Gulzar, Thomas S. van Zanten, Dhruv Sheth, Neeraja Subhash, Anchal Chandra, Akshatha Shivaraj, Patricia Panikulam, Ibrahim U, Vijay Kumar Nuthakki, Theja Parassini Puthiyapurayil, Riyaz Ahmed, Ashaq Hussain Najar, Sai Manoz Lingamallu, Snigdhadev Das, Bhagyashri Mahajan, Praveen Vemula, Sandip B. Bharate, Parvinder Pal Singh, Ram Vishwakarma, Arjun Guha, Varadharajan Sundaramurthy, Satyajit MayorA: For the experiment described in Figs 6B and 6C, images are shown in 6B and S7A and quantification in Fig 6C. p-value table is indicated in S1 Table. B, C: For the experiment described in Fig 6D and 6E, images including pH maps are shown in Figs 6D and S7B and quantification in Figs 6E and S7C. FITC and TMR endosomal intensities and numbers of endosomes are quantified in S7C. Niclosamide increases FITC intensity, reduces numbers of endosomes and has minimal effect on TMR intensity. p-value table is indicated in S1 Table.
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pH-dependent endocytic pathwayuptakeinhibitionNH 4 ClNiclosamideACE 2. Ectopic expressionattenuates Spike-pseudovirus entryEndosomal acidification inhibitorsCLICSARS-CoV -2SARS-CoV -2 spike proteinBafilomycinA 1endosomal pHCGinfectiontarget SARS-CoV -2 entryAGS-ACE 2 cellsSARS-CoV -2 entry inhibitorreceptor binding domainRBDhost endo-lysosomal network
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