Identification of 13 common driver mutations with weak HLA affinity.

Bar plot shows the effect size (%) of the 20 driver mutations in the dataset with the largest effect. This effect was determined by comparing a driver mutation’s odds ratio (logistic regression, within-patient model) before and after exclusion, as illustrated in the inset for BRAF V600E. Mutations with an effect size larger than 1% (dashed line, dark bars) were considered weak HLA affinity mutations. Exclusion of these 13 mutations resulted in a complete removal of any effect (inset).