pone.0254125.g005.tif (514.63 kB)
ICI blockade does not inhibit LL/2 or LL/2-tdTomato/Luc tumor growth.
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posted on 2021-08-19, 17:27 authored by Lei Huang, Ramireddy Bommireddy, Luis E. Munoz, Rohini N. Guin, Changyong Wei, Amanda Ruggieri, Ashwathi P. Menon, Xiaoxian Li, Mala Shanmugam, Taofeek K. Owonikoko, Suresh S. Ramalingam, Periasamy Selvaraj(A) Experimental design of the in vivo study (n = 5). (B) Tumor size of mice treated with anti-PD-1 or anti-CTLA-4 mAb. Mean ± SEM is plotted. Significance of differences was determined by using unpaired student t-test. Values of p<0.05 were considered significant.
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conduct studiestdTomatotumor-infiltrating lymphocytescell lineLewis lung carcinomaTILtumor microenvironmentmurine lung cancerLLtumor Imaging techniquesanti-CTLA -4 antibodiesgrowth rateimmunocompetent syngeneic tumor tra...visualizing tumor progressionanimal modelstumor-induced myeloid-derived suppr...immunocompetent animal modelstumor growthMDSC
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