Fig 1.tif (5.98 MB)
Hypercholesterolemia induced cerebral small vessel disease - Fig 1
figure
posted on 2017-08-10, 17:40 authored by Peter Kraft, Michael K. Schuhmann, Cornelia Garz, Solveig Jandke, Daniela Urlaub, Stine Mencl, Alma Zernecke, Hans-Jochen Heinze, Roxana O. Carare, Christoph Kleinschnitz, Stefanie SchreiberA) Intravascular accumulation of erythrocytes (referred to as erythrocyte stases) in the capillaries and arterioles of 6 and 12 months old WT and Ldlr-/- mice. Importantly, 6 months old Ldlr-/- animals showed the highest number of stases. Analysis of variance with Bonferroni post-hoc test, * P < 0.05, P < 0.01. B) Histological Hematoxylin–Eosin stainings of cortical tissue of 6 and 12 months old WT and Ldlr-/- mice (20x magnification). Erythrocyte accumulations are marked with arrows and accentuated in the inserts with higher magnification (40x). WT, wild-type; FOV, field of view. Error bars indicate standard deviation.
