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Hydroxylated lysines and prolines become glycosylated, fibres come together to form triple helixes and get transported out of the ER.

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posted on 2021-11-08, 18:25 authored by Sharon Flanagan, Áine Rowe, Vivienne Duggan, Erin Markle, Maureen O’Brien, Gerald Barry

Hydroxylation (red) is crucial for the crosslinking of fibres and improving the strength of the collagen bundles. This does not happen properly if hydroxylation is faulty as is the case in WFFS.

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    time pcr assaysingle nucleotide changeplod1 gene encompassingequine plod1 genedisease typically diecausative genetic mutationautosomal recessive conditiontest requires amplificationhigh throughput analysiscomputational analysiscommercial testthus increasingreliably differentiatesposition 2032large numbersfoals affectedeuthanised shortlycurrently availablecornell universitycompanies operatingaffected foals

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