HuCD3ε-bearing T cells develop functional immune responses.

(A) Splenocytes from 3–4 month old mice from WT or huCD3ε^HET mice were injected i.v. into 8–9 week old, 800 rads irradiated, B6D2 mice and graft-vs-host disease developed in vivo after a week post-injection. Percent body weight change is shown (A). n = 3–7, *p<0.05. (B-C) 2–4 month-old mice WT and huCD3ε^HET were immunized against ovalbumin or NP-CGG and administered a booster shot on day 14. Antibody titers were measured on day 10-post immunization (primary response) (B) or seven days following booster shot (secondary response) (C) for each antigen. n = 10, *p<0.05.