pone.0253912.g004.tif (3.73 MB)
Histological analysis of WT and KO mice.
figure
posted on 2021-07-01, 17:36 authored by Yuko S. Niino, Ikuo Kawashima, Yoshinobu Iguchi, Hiroaki Kanda, Kiyoshi Ogura, Kaoru Mita-Yoshida, Tomio Ono, Maya Yamazaki, Kenji Sakimura, Satomi Yogosawa, Kiyotsugu Yoshida, Seiji Shioda, Takaya Gotoh(A) Comparison of heart and spleen sizes between WT and KO mice. Arrow indicates the site of deformity in the lung. Scale bars represent 2 mm. (B) Hematoxylin and eosin-stained images of hearts, lungs, and spleens from WT and KO mice. The heart image shows a cross-section. Scale bars represent 1 mm for the heart and spleen and 200 μm for the lung. Arrow indicates the site of calcification. (C) Heart of a KO mouse with internal calcification. Arrow indicates the site of calcification. (D) Hematoxylin and eosin-stained images of vertically cut hearts from KO mice. Inset shows calcification at the base of the mitral valve. Scale bars represent 1 mm. Arrow indicates the site of calcification.
