Heat map of relative TK mRNA expression levels among MIBC patient tumor samples.

TCGA data for MIBC patient tumor samples (n = 408) reported previously [22]. TK gene symbols are listed vertically at right. Samples are grouped on the horizontal axis by mRNA subtype classifications as defined by Robertson et al. [22] indicated at the top (from left to right): neuronal (N, green); basal squamous (BS, red); luminal (L, gray); luminal infiltrating (LI, gold); luminal papillary (LP, purple). TK genes are clustered hierarchically; in the cladogram at left cabozantinib targets are designated with violet squares.