pone.0254305.g001.tif (373.9 kB)
HSA surface modification.
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posted on 2021-09-30, 17:30 authored by Nikita Lomis, Susan Westfall, Dominique Shum-Tim, Satya PrakashSchematic representation of AT1 peptide conjugation to HSA surface through a two-step chemical covalent reaction using fluorescent heterobifunctional cross-linkers.
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lacking target specificityexhibits low bioavailabilityexhibit superior targetingcovalent conjugation reaction9 ± 18 ± 2improves myocardial contractility4 ± 14 %, respectively2 ± 4overexpressing at1 receptorsh9c2 cells treateddrug delivery characteristicsdiv >< pcongestive heart failuretargeted cardiac uptakeheart failureh9c2 cellstargeted drugtargeted deliverymyocardial infarctioncardiac functionzeta potentialvs 44vivo vasodilatory effectssurface functionalizedsignificantly highernanoparticle sizeintracellular uptakehypertrophic conditionscumulative releaseangiotensin ii7 nm7 mv24 hrs
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