ppat.1010162.s003.tif (1.22 MB)
Gross pathological pulmonary pathology in SARS-CoV-2 infected pigtail macaques (PTM).
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posted on 2021-12-20, 18:43 authored by Alexandra Melton, Lara A. Doyle-Meyers, Robert V. Blair, Cecily Midkiff, Hunter J. Melton, Kasi Russell-Lodrigue, Pyone P. Aye, Faith Schiro, Marissa Fahlberg, Dawn Szeltner, Skye Spencer, Brandon J. Beddingfield, Kelly Goff, Nadia Golden, Toni Penney, Breanna Picou, Krystle Hensley, Kristin E. Chandler, Jessica A. Plante, Kenneth S. Plante, Scott C. Weaver, Chad J. Roy, James A. Hoxie, Hongmei Gao, David C. Montefiori, Joseph L. Mankowski, Rudolf P. Bohm, Jay Rappaport, Nicholas J. ManessA-D. Gross pulmonary pathology at 6- (A and B) and 21-days post infection (dpi, C and D). A. MA27, the left caudal lung lobe has multifocal tan-plum areas of consolidation (arrows). Inset: the consolidation extends to the diaphragmatic and medial surface of the left caudal lung. There is no evidence of gross pathology in MA30 (B) or MA24 (C). D. MA28, the laterodorsal aspect of the left caudal lobe contains two small, flat tan foci (arrows). Inset: closer view of tan foci.
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severe cardiovascular symptomsmacaca nemestrina highly transmissible variantsexpress cytotoxic moleculesdiv >< palso noted increasesthus may servesiv ), includingpulmonary pathologic lesionspredominantly cd4 +.pigtail macaque (<respiratory viral challengeuseful animal modelsimian immunodeficiency virussevere disease coursenovel coronavirus sarsreveals new immunereveals newincluding cd4thus proposedpulmonary infiltratespigtail macaquesimmune dynamicsanimal models>) modelviral dynamicsupregulate cd8understanding mechanismstesting vaccinesstudying pathogenesisneutralizing antibodiesinfections risingextensively studieddecember 2021data demonstratecomplex signaturescoagulation markerscausative agentassessing sars>) demonstrate2 viral
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