ppat.1011815.g004.tif (235.25 kB)
Gray matter vacuolation profiles for sheep inoculated with the WTD scrapie agent.
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posted on 2023-12-04, 18:34 authored by Robyn D. Kokemuller, S. Jo Moore, Jifeng Bian, M. Heather West Greenlee, Justin J. GreenleeArea codes for specific brain regions are defined in Table 2. Variations in vacuolation scores between sheep of different genotypes challenged with same inoculum and between sheep of the same genotype challenged with different inocula. Similar vacuolation scores were seen in VRQ/VRQ sheep that received WTD cerebrum (sheep 1 and 2). ARQ/ARQ sheep (sheep 3) and the VRQ/VRQ sheep (sheep 6) had lower vacuolation scores compared to the VRQ/VRQ sheep challenged with the WTD cerebrum. Significant differences were seen between sheep 1 and 3 (*) and sheep 1 and 6 (**). Sheep 4 was omitted due to all areas receiving a score of 0 for vacuolation.
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represents one examplenew strain propertiesnecropsied upon development72 months postprion agents occurmisfolded prion proteinshorter incubation periodsfastest incubation occurringsimilar incubation periodssc immunohistochemistry demonstrated prpdiv >< pinfluence disease phenotypewtd scrapie ).classical sheep scrapie13 – 7vrq sheep ).wtd scrapiedisease phenotypeinoculation ).rapid incubationfaster incubationsimilar patternsscrapie agentprion strainsphenotype switchphenotype changevrq sheep10 sheep124 scrapiewestern blotovinized miceoronasally challengedmultiple linesmouse bioassaymarkedly differentinterspecies transmissionevidence suggestenzyme immunoassayconformational stabilityclinical signsbrain tissuesattack rate7 inoculum
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