pone.0293774.g003.tif (584.06 kB)
Graphical representation of PARKEX study design.
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posted on 2023-11-24, 00:26 authored by Juan Carlos Magaña, Cláudia Maria Deus, Laura Baldellou, Merce Avellanet, Elvira Gea-Rodríguez, Silvia Enriquez-Calzada, Ariadna Laguna, Marta Martínez-Vicente, Jorge Hernández-Vara, Maria Giné-Garriga, Susana Patricia Pereira, Joel MontaneStudy design highlighting the interventions and respective experimental groups, timing of sample collection, and analyzed.
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striatal dopamine deficiencyrelated neuronal losspatients &# 8217pathogenic processes correlatingparkinson &# 8217bptfe ), targetingameliorate neurological impairmentsundergo bpt combinedpatient skin fibroblastsparkex study aimsstage pd patientsskin fibroblaststhree agesurrogate indicatorssensorimotor pathwayssedentary groupsed ).physical activitypd pathogenesisoxidative stressmotor trainingmotor functionmitochondrial functionmitochondrial dysfunctionmitochondrial bioenergeticsmetabolic remodelingmetabolic improvementmatched groupsimpede agegroup 3group 2group 1functional exercisesethical approvalemphasizing strengthconducted preclinical measures12 weeks
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