pcbi.1011847.g005.tif (488.82 kB)
Granuloma oxygen and glucose profile estimates.
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posted on 2024-02-09, 18:36 authored by Meenal Datta, McCarthy Kennedy, Saeed Siri, Laura E. Via, James W. Baish, Lei Xu, Véronique Dartois, Clifton E. Barry 3rd, Rakesh K. JainDimensionless concentration, f, of oxygen (A) and glucose (B) as a function of dimensionless granuloma radius, ξ, for increasing values of dimensionless granuloma size (the modulus α0).
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resolved experimental resultsrat carcinoma modelsexplore additional aspectsapproximate analytical solutionsinterstitial fluid velocityinterstitial fluid pressureprior experimental resultstb )– compromiselimited oxygen availabilityavascular oxygen diffusionimprove molecular transportdiv >< prabbit tb granulomasinterstitial convectionprior studiesoxygen transporttranscapillary transportsilico plasma dilutionphysiological abnormalitiesnecrosis emergemouse modelmathematical modelinitial modelgranuloma vasculaturegranuloma microenvironmentglucose concentrationdrug transportdirect resultdemonstrated mathematicallyconvective zonecellular metabolism
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