pcbi.1011847.g004.tif (415.49 kB)
Granuloma convective zone thickness estimates and comparisons to experimental granuloma data.
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posted on 2024-02-09, 18:36 authored by Meenal Datta, McCarthy Kennedy, Saeed Siri, Laura E. Via, James W. Baish, Lei Xu, Véronique Dartois, Clifton E. Barry 3rd, Rakesh K. JainDimensionless convective zone thickness, λΔ (lines), as a function of dimensionless granuloma size (0 < α0 < 30) for varying values of dimensionless limiting perfusion velocity, (as defined in the S1 Text), in comparison to experimental data from rabbit TB granulomas [15] (gray dots).
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resolved experimental resultsrat carcinoma modelsexplore additional aspectsapproximate analytical solutionsinterstitial fluid velocityinterstitial fluid pressureprior experimental resultstb )– compromiselimited oxygen availabilityavascular oxygen diffusionimprove molecular transportdiv >< prabbit tb granulomasinterstitial convectionprior studiesoxygen transporttranscapillary transportsilico plasma dilutionphysiological abnormalitiesnecrosis emergemouse modelmathematical modelinitial modelgranuloma vasculaturegranuloma microenvironmentglucose concentrationdrug transportdirect resultdemonstrated mathematicallyconvective zonecellular metabolism
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