pcbi.1011847.s005.tiff (32.1 MB)
Granuloma IFP estimates from the shell-core model.
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posted on 2024-02-09, 18:36 authored by Meenal Datta, McCarthy Kennedy, Saeed Siri, Laura E. Via, James W. Baish, Lei Xu, Véronique Dartois, Clifton E. Barry 3rd, Rakesh K. JainPredicted dimensionless (A) IFP and (B) IFP profiles within granulomas for different moduli α0 and for the shell-core perfusion model, with ξD = 0.5.
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resolved experimental resultsrat carcinoma modelsexplore additional aspectsapproximate analytical solutionsinterstitial fluid velocityinterstitial fluid pressureprior experimental resultstb )– compromiselimited oxygen availabilityavascular oxygen diffusionimprove molecular transportdiv >< prabbit tb granulomasinterstitial convectionprior studiesoxygen transporttranscapillary transportsilico plasma dilutionphysiological abnormalitiesnecrosis emergemouse modelmathematical modelinitial modelgranuloma vasculaturegranuloma microenvironmentglucose concentrationdrug transportdirect resultdemonstrated mathematicallyconvective zonecellular metabolism
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