Germ cell atypia

Copyright information:

Taken from "Testis and Antler Dysgenesis in Sitka Black-Tailed Deer on Kodiak Island, Alaska: Sequela of Environmental Endocrine Disruption?"

Environmental Health Perspectives 2005;114(S-1):51-59.

Published online 21 Oct 2005

PMCID:PMC1874179.

This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI

() Atypical germ cells (arrows), characterized by abnormal nuclei, pale cytoplasm, and perinuclear cytoplasmic inclusions, in the testis of NCO deer 03-10. These abnormal germ cells are CIS-like cells, also called intratubular germ cell neoplasia. Note the location of these cells in the basal compartment of a seminiferous tubule (where premeiotic germ cells are normally located). Primary spermatocytes and spherical spermatids are seen adluminally. PAS and hematoxylin staining. () Atypical germ cells in a seminiferous tubule lacking any normal germ cell. Arrow designates a mitotic figure. Note foamy, hypertrophic Leydig cells. Differential interference contrast microscopy. Scale bars = 25 μm.