Gb-2003-4-7-r45-1.jpg (67.38 kB)
Genome reinvestigation using comparative genomics
figure
posted on 2011-12-30, 14:08 authored by Sophie Brachat, Fred S Dietrich, Sylvia Voegeli, Zhihong Zhang, Larissa Stuart, Anita Lerch, Krista Gates, Tom Gaffney, Peter PhilippsenCopyright information:
Taken from "Reinvestigation of the genome annotation by comparison to the genome of a related fungus: "
Genome Biology 2003;4(7):R45-R45.
Published online 25 Jun 2003
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC193632.
Copyright © 2003 Brachat et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
Translated DNA comparison allows the detection of homology outside annotated features of a query genome. This can lead to the detection of novel ORFs, novel introns/exons, ORF extensions, and ORF fusions (fusion of adjacent ORFs or merging of overlapping ORFs with same transcription direction). Gray areas illustrate regions of homology at the protein level and dashed lines depict suggested modifications in the query genome. Cases of changed splice sites may also be detected but are not drawn here.