pgen.1010540.g007.tif (309.84 kB)
Genome-wide Manhattan plot.
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posted on 2022-12-12, 18:38 authored by Martin Jankowiak, Fritz H. Obermeyer, Jacob E. LemieuxWe depict BVAS hits as a Manhattan plot of the entire SARS-CoV-2 genome, with gene boundaries indicated on the horizontal axis. We do not include the small number of hits with negative selection coefficients (in particular ORF1b:K1383R, ORF1a:A2554V, ORF1b:S959P, and ORF1a:G697R).
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relative growth ratespivotal role playedpairwise interaction effectsallele frequency spacescalable probabilistic methodless well characterizedidentify numerous mutations9 million sarsinferring selection effectsdifferential viral fitnessselection actsviral lineagesviral evolutionxlink ">vaccination statusunprecedented viewspike proteinsequence millionsnucleocapsid proteinsn501 residuelasting vaccinesincrease fitnessidentifying fitnessglobal effortgenetic determinantsdiffusion approximationdeveloping effectivebvas ),baseline modelassociated mutationsapply bvasanalyses point
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