pone.0291892.g004.tif (1.24 MB)
Generation of P822L in PLpro.
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posted on 2024-03-14, 17:40 authored by Amirah Azzeri, Nurul Azmawati Mohamed, Saarah Huurieyah Wan Rosli, Muttaqillah Najihan Abdul Samat, Zetti Zainol Rashid, Muhamad Arif Mohamad Jamali, Muhammad Zarul Hanifah Md Zoqratt, Muhammad Azamuddeen Mohammad Nasir, Harpreet Kaur Ranjit Singh, Liyana Azmi(A) Apo form of Bat SARS-CoV PLpro homodimer represented in cartoon with zinc (orange spheres) The P822L was generated and visualised using PyMOL. Here, we present a (B) zoomed view of WT residue P822 and (C) mutated L822.
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values &# 8212using molecular dynamicsmuch stabler proteinenforce control measurescorrelation analysis showedhighest occurring mutationsamino acid mutationshigher mutation ratescertain patients get2 mutation frequenciesp822l mutationhigher numberfrequency analysistracking emergencethus deservesignificant tendencysettings especiallysequencing surveillancesequencing platformsplpro representsplpro proteaseorf1a regionoccur withinnsp3 p822lnovel variantsincome countieshelp determinegenomic surveillanceconsistent radiusclinical status
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