pone.0293636.g002.tif (708.45 kB)
Gene expression profile in skeletal muscle of sedentary mice.
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posted on 2023-11-02, 17:51 authored by Brigitte Jia, Alexander Hasse, Fubiao Shi, Sheila Collins(A) The mRNA levels of (A) NP receptor genes Nprc, Npra and Nprb; (B) Pgc1α and Ucp3 in the tibialis anterior (TA) and soleus (SO) muscles of control and Nprc MKO mice. Two-way ANOVA, ** p < 0.01; *** p < 0.001; **** p < 0.0001; and p>0.05, no statistical significance.
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three npr genesregulating blood pressurenpr ): npracell type determinesthermogenesis gene programmaximal running velocityadditional physiological conditionscgmp signaling pathwaytype natriuretic peptidesthree np receptorsskeletal muscle knockoutsince nprc functionsmajor metabolic effectsdiv >< pc2c12 myocytes treatmentskeletal muscle deletionfloxed control miceskeletal musclenatriuretic peptidesgene deletionskeletal myocytesc2c12 myocytesvoluntary runningsedentary conditionsfloxed littermatessignaling strengthnp signalingwheel trainingwell understoodvivo treadmill trainingstudy suggestsstimulate lipolysispotentially importantnprc muscle functiongenetic modelexercise performancecnp evokescardiovascular homeostasisbaseline values
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