pntd.0009940.s002.tif (4.61 MB)
Gating strategy for cytokines.
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posted on 2021-11-12, 18:36 authored by Brenda Rocamonde, Nicolas Futsch, Noemia Orii, Omran Allatif, Augusto Cesar Penalva de Oliveira, Renaud Mahieux, Jorge Casseb, Hélène DutartreExample of the gating strategy for cytokine determination in AC and HAM/TSP group for IFNα, IL-12 MIP-1α and TNFα in the different cell subsets.
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tropical spastic paraparesissup >+pdc producing ilcell leukemia virushigher ifnγ responsivenessdevastating neurodegenerative diseasemonocytes producing mipincluding asymptomatic carriersdiv >< ptsp patients comparedtsp blood samplesblood samplesasymptomatic carrierstsp patientstsp comparedhigher frequencydisease occurrencedisease manifestationsteady statesignaling pathwaypotential consequencenk cellsneuroinflammatory statusmechanism underlyinglower responselike receptorinflammatory responseinfected volunteersincreasing numberincreased sensitivityimmune cellseffective treatmentcorticosteroid treatmentsadaptive compartment
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