Fundus photographs of an eye with neovascular AMD which was diagnosed as normal, using Optos^® and digital fundus photograph.

(A) Imaging obtained by Clarus^TM (B) OCT imaging shows inactive occult CNV. (C) Clarus^TM imaging with 50-degree field of macula shows the area of retinal pigment epithelium (RPE) alteration in the macula (white arrowhead); two masked graders classified the image as neovascular AMD; (D) Optos^® imaging shows unclear RPE alteration; one masked grader classified the image as neovascular AMD while the other grader and the third grader also diagnosed it as normal; (E) Digital fundus photograph shows obscure RPE alteration; one masked grader classified the image as neovascular AMD while the other grader and the third grader also diagnosed it as normal.