pone.0260841.g004.tif (432.55 kB)
Full-length and partially truncated forms of E1inhibit cell proliferation.
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posted on 2021-12-30, 18:29 authored by Fern Baedyananda, Arkom Chaiwongkot, Shankar Varadarajan, Parvapan BhattarakosolHEK 293T cells were transfected with either the vector control (pEGFP), full-length HPV16 E1(pEGFP-E1) or one of the truncated forms (pEGFP-E1-184, pEGFP-E1-359, and pEGFP-E1-439). Cell count was analysed using CountBright™ beads and flow cytometry.
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spectrum caspase inhibitorrpl36a ), metabolismreal time rtgenetic changes contributedetermine whether expressioncellular proliferation (<host dna damagehost gene expressiondiv >< pcervical cancer progressionnecrotic cell deathhpv16 e1 correlatedcervical cancercell proliferationcell deathprolonged expressioncell viabilitytruncated formsstudy aimedsimilar effectsignificant reductionprotein synthesisprominent causepossible rolepartially inhibitedp immune responsehpv16 e6hpv16 e1helicase requiredhek293t cellsgenes involvede7 oncoproteins>- value0001 ).
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