pone.0297861.s003.tif (1.06 MB)
Forest plot of SNPs associated with malignant tumor of kidney and their risk of different types of systemic autoimmune diseases after outliers removal with MR-PRESSO and tightening instrument P value threshold.
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posted on 2024-02-29, 18:46 authored by Puyu Liu, Jihang Luo, Lanlan Zhao, Qingqing Fu, Yao Chen, Chengfang Li, Jieyu Xu, Xiaorong YangForest plot of SNPs associated with malignant tumor of kidney and their risk of different types of systemic autoimmune diseases after outliers removal with MR-PRESSO and tightening instrument P value threshold.
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systemic autoimmune diseaseseveral autoimmune diseasesquality control stepsprovide new insightssubacute iridocylitis (<single snp analysisconsistent without heterogeneity>), juvenile rheumatismanalyze genetic causalityinverse variance weightingwide association studyivw ), mrgenetic causalitywide genomevariance weightedcoxarthrosis (<study suggestsstudy exploresgwas ),evaluate causality897 ),xlink ">weighted modelweighted mediantemporal naturetake seriouslysimple modelsensitivity analysisscale genomerenal malignancyrenal malignanciespotential riskpotential impactpooled datapleiotropic testingodds ratiomultiple malignanciesinstrumental variablesincreased riskevaluate pleiotropydifficulty indeterminingconfidence intervalcausal relationship869 483 1 077 073 051 014 009 008 006 002
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