pcbi.1011252.g008.tif (129.64 kB)
Flow rerouting.
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posted on 2024-02-16, 18:33 authored by Jakub Köry, Vedang Narain, Bernadette J. Stolz, Jakob Kaeppler, Bostjan Markelc, Ruth J. Muschel, Philip K. Maini, Joe M. Pitt-Francis, Helen M. ByrneFlow is rerouted in this section of a forking network (α = 1.1, μm) when a single vessel is pruned (original position marked with an asterisk) between (A) and (B) and the flow rate increases in four hypoperfused vessels (blue) to the extent that they become perfused (red).
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small mean diametersnovel computational modelconsidering network compositionangiogenic sprouts showtumour angiogenesis leadsalso identify casessupport blood flowdiv >< pperfusion increases duepoor blood perfusionoptimal irradiation strategyoptimal strategytumour ’largest increasesidentify tumoursblood perfusionperfusion postperfusion enhancementvivo vascular tumoursvascular networkssynthetic tumoursspatially heterogeneoussilico results indicateregular deploymentoxygen heterogeneitylarge numbersincreased hypoxiaimaging datagood candidatescombination therapiesarchitectural features
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