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posted on 2022-03-16, 17:26 authored by Tamara Kreiss, Tyler Eck, Brittany Hart, Sreedhar Tummalapalli, David Rotella, John SiekierkaBiological functions affected by treatment of B. malayi males with 100 nM of MSU-TSR-6-44 (A and B) or MSU-TSR-6-38 (C and D). Gene classification was conducted with the Panther Classification System Gene Analysis tool, using the B. malayi Genome as a reference. (Mi H et. al. 2018; Mi H et. al. 2019).
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structural comparison searchsevere side effectsmedicinal chemistry effortsdiv >< pclose structural similarityloa loa </histone demethylase inhibitorsbrugia malayi </potent killing activityadult filarial parasitesmalayi </adult parasitesminimal activityhistone methylationb </parasites treatedfilarial drugstoxic liabilitiesscreening programresults indicatepotential antiparasitic nematodesparasitic eyewormparasite responsiblenovel seriesnovel approachnew classmight indicatemicrofilariae killingmajor causelimited efficacylife threateninglarval formslargely usedkilling microfilariaeinsect vectorsindividuals throughoutdrug actioncontraindicative duechronic morbidityaffects millions
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