Fig 6 -

Microarray gene expression analysis revealed that tumors with Zmiz1 SB insertions (yes) had significantly higher expression of Zmiz1 compared to tumors without insertions (no) (A). Box boundaries indicate interquartile range; whiskers indicate maximum and minimum values; center lines indicate medians. (B) Insertion read depth for SB in the Zmiz1 locus positively correlates with Zmiz1 expression by microarray analysis. (C) Top 25 differentially expressed genes between genomes with (yes) or without (no) Zmiz1 SB insertions (D) Normalized gene expression of top differentially expressed genes, Riok1, Mtdh, Anp32e, Trappc5, Set, Tef, Wdr13, Tcrb-J with corrected P<0.05 from panel C, in cuSCCs with SB-driven Zmiz ^△N185 expression. Additional KA tumors from Pten-sensitized mice using keratinocyte-specific SB mutagenesis (S1 Text).