figshare
Browse
pone.0297803.g005.tif (2.88 MB)

Fig 5 -

Download (2.88 MB)
figure
posted on 2024-02-15, 18:42 authored by Alexandra Gaspar-Pintiliescu, Laura M. Stefan, Elena Mihai, Catalina Sanda, Vasile S. Manoiu, Daniela Berger, Oana Craciunescu

Micrographs of live (green) and dead (red) Hep-2 cells treated with different concentrations of Rapana venosa GAG extract, before and after digestion with heparinase III (Hep III) and chondroitinase ABC (Chase ABC), for 72 h, assessed by Live/Dead assay (A). Scale bar = 50 μm. Histogram of cell viability determined by ImageJ analysis (n = 3) (B).

History

Usage metrics

    PLOS ONE

    Categories

    Keywords

    novel bioactive compoundinhibit cell proliferationimportant pharmacological applicationsfree radical scavengingfourier transform infrareddiv >< pdead assays showedagarose gel electrophoresis2 cell culturestumoral cell migrationheparinase iii indicatedrapana venosa bovine heparan sulfatehigh antioxidant activityvenosa heparan sulfatespectra indicatedantioxidant activityvitro sulfate contentr extract migrationchondroitin sulfateunique moleculessulfation ratiospecific digestionslightly decreasedscarce informationpotential usemarine snailmarine glycosaminoglycansmain componenthuman hepenzymatic treatmentenzymatic digestionelemental compositiondifferent invertebratescytocompatible concentrationschondroitinase abccapacity decreasedbiomedical useantiproliferative propertiesantiproliferative effectantiproliferative activitiesalso inhibited

    Licence

    CC BY 4.0

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC