pone.0297803.g004.tif (383.59 kB)
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posted on 2024-02-15, 18:42 authored by Alexandra Gaspar-Pintiliescu, Laura M. Stefan, Elena Mihai, Catalina Sanda, Vasile S. Manoiu, Daniela Berger, Oana CraciunescuCell viability of normal L929 cells (A) and tumor Hep-2 (B) cells after cultivation with different concentrations of marine GAG extract from Rapana venosa, before and after enzymatic digestion with heparinase III (Hep III) and chondroitinase ABC (Chase ABC) for 72 h, assessed by MTT assay. The results are expressed as mean values ± SD (n = 6). *p<0.05, compared to negative control (C-).
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novel bioactive compoundinhibit cell proliferationimportant pharmacological applicationsfree radical scavengingfourier transform infrareddiv >< pdead assays showedagarose gel electrophoresis2 cell culturestumoral cell migrationheparinase iii indicatedrapana venosa bovine heparan sulfatehigh antioxidant activityvenosa heparan sulfatespectra indicatedantioxidant activityvitro sulfate contentr extract migrationchondroitin sulfateunique moleculessulfation ratiospecific digestionslightly decreasedscarce informationpotential usemarine snailmarine glycosaminoglycansmain componenthuman hepenzymatic treatmentenzymatic digestionelemental compositiondifferent invertebratescytocompatible concentrationschondroitinase abccapacity decreasedbiomedical useantiproliferative propertiesantiproliferative effectantiproliferative activitiesalso inhibited
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