Fig 2 -

A) Zoomed simulation snapshot of the 3D Vertex model with heterotypic interfacial tension between cells of different types. B) Cell shape s as a function of the magnitude of heterotypic interfacial tension σ for cells that are adjacent to the boundary (solid lines) and cells that are in the bulk and do not share a heterotypic interface (dashed lines). In both models, the shape index of the boundary cells increases, while the shape index of the bulk cells decreases as a function of increasing interfacial tension. Error bars represent the standard error with respect to each ensemble. C) The probability distribution (pdf(z)) of the heights of cell centers (z) reported in natural length units from the bottom of the box. Different colors correspond to different magnitudes of the heterotypic interfacial tensions σ ∈ 0.04, 0.08, 0.16, 0.32, 0.64 from light pink to dark magenta. D) The registration of cell centers on either side of the interface (defined by Eq 4) increases for Voronoi (green) and vertex (magenta) models as a function of increasing interfacial tension. Error bars represent the standard error.